4E-BP1 EXPRESSION IN EMBRYONIC POSTMITOTIC NEURONS MITIGATES MTORC1-INDUCED CORTICAL MALFORMATIONS AND BEHAVIORAL SEIZURE SEVERITY BUT DOES NOT PREVENT EPILEPSY IN MICE

Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) pathway during neurodevelopment leads to focal cortical malformations associated with intractable seizures.Recent evidence suggests that dysregulated cap-dependent translation downstream of mTORC1 contributes to cytoarchitectural abnormalities and seizure activity.Here, we ex

Millennial generation workforce is a new emerging generation and soon will become dominant workforce in Indonesia.Sadly, millennial generation has high turnover intention in Indonesia.Millennial employee turnover intention is a new problem for human resources because millennial employee has different characteristic compare to its predecessor.Theref

Medical Wedding attention to vision impairment and associated eye care complications are a vital component of daily living and overall well-being.In the United States today, the physician to patient deficit places great strain on the availability of medical attention tenable to patients nationwide; in terms of specialty medicine, this deficit is ev

BackgroundHypochondriac symptoms are commonly reported in health science students.With their incomplete medical knowledge, they may compare their own bodily symptoms with disease symptoms during the process of learning, which can lead to mental distress and the need for repeated medical reassurance.ObjectiveTo estimate the prevalence of hypochondri

Abnormal mitochondrial function resulting in inadequate energy supply leads to sarcopenia and IR, suggesting that maintaining mitochondrial homeostasis by regulating mitophagy may be a promising strategy for sarcopenia IR therapy.Herein, we Mouthguard constructed sarcopenia mice model, which was treated with berberine and/or SIRT1/mitophagy inhibit